CasX: the smaller the crispier

cas treeTime will tell if it is going to become the preferred enzyme for genome editing or just another useful tool in the expanding CRISPR kit. But the future of CasX looks bright. It is much smaller than the nucleases that have provided a foundation for this technology. Being fewer than a thousand amino acids, it offers clear advantages for delivery in comparison with Cas9, that is over 1,300 Aa. Continue reading

Lights. Camera. Action. Cut!

Super cool. The best film I’ve seen in years. I’m speechless. Over 3,000 retweets and dozens of ecstatic comments, this is how Twitter has reacted to the first real-time video featuring CRISPR, posted by Hiroshi Nishimasu of the University of Tokyo. It is not an animation clip, and it truly shows the Cas9-RNA complex paparazzed while doing its molecular job. Continue reading