History in the making: student experiment edits DNA with CRISPR technology in space (Iss national lab blog)
Emails reveal that a facility in Dubai and others have asked geneticist He Jiankui for help in gene-editing embryos (The Scientist)
New worries about CRISPR babies: gene edits might have shortened their life expectancy (Nature)
Never at the top of front pages (Nyt, 27 Nov. 2018)
Twenty days after the announcement, many questions remain. The one certainty seems to be that the first CRISPR babies are less breaking news than expected.
They will be in front pages again, probably, if and when the scientific paper gets published, if and when the baby-editor He Jiankui resurfaces, if and when the first photos of Lulu and Nana are circulated. But if the coverage of Dolly the sheep is considered in comparison, there’s no match. Why?
The media world has changed dramatically in the meantime, CRISPR is still unknown to many, China is perceived as a Wild East where anything can happen. But a sheep is always a sheep, and babies are babies. We should care about the first edited kids more than that. Maybe people are less troubled by human genome editing than most bioethicists. Perhaps the media have had enough of Gattaca, Frankenstein, and the likes. Did we cry wolf too often yesterday to get people interested today?
Don’t miss the “Draft Ethical Principles for Therapeutic Assisted Reproductive Technologies” just published by He Jiankui et al. in The CRISPR Journal. It seems the Lulu and Nana’s experiment is at odds even with their own guidelines. We are eager to hear more from He’s voice, his talk in Hong Kong is scheduled on Wednesday, 28 November 2018 (Second International Summit on Human Genome Editing-live broadcast)
“Agricultural research, or a new bioweapon system?”. This is the question asked by Guy Reeves et al. in a policy forum published in Science today. The evolutionary geneticist from the Max Planck Institute and his German and French coauthors doubt that the Insect Allies program funded by Darpa in the US will realize significant agricultural benefits, e.g. in relation to drought, frost, flooding, herbicide, salinity, or disease. They fear, indeed, that it will be “widely perceived as an effort to develop biological agents for hostile purposes and their delivery, which – if true – would constitute a breach of the Biological Weapons Convention.” Continue reading
A shortlist of articles capturing ag scientists’ dismay at the recent EU verdict affecting the future of CRISPR crops:
Science Media Centre, Expert reaction to Court of Justice of the European Union ruling that GMO rules should cover plant genome editing techniques
Matt Ridley, EU’s anti-GMO crusade is unscientific and harmful
Mark Lynas, Scientific community defeated by green groups in European court ruling on gene edited crops
Carl Zimmer, What is a genetically modified crop? A European ruling sows confusion
The Observer view on Europe’s ban on gene-editing crops
Wired, European ruling could slow Africa’s push for CRISPR crops
A paper published in Nature Biotechnology by Allan Bradley and colleagues from the Wellcome Sanger Institute in Hinxton, UK, shows that classical CRISPR editing can cause large rearrangements of DNA near the target site in actively dividing cells. We may think of it as the latest CRISPR alarm, but also as a demonstration of how biomedical research works. Firstly: no technology is perfect, but the best ones are perfectible. CRISPR belongs to this category because it is an extraordinarily versatile and fast-evolving biotech platform. When reading news like “CRISPR causes this or that problem,” the first question to ask is: which CRISPR variant are we talking about? Continue reading