Do you remember the first lab mice equipped with (almost) working CRISPR-based gene drives? The results were pre-printed in bioRxiv last July, but the paper by Kimberly Cooper and colleagues is published in Nature today. The University of California San Diego has made a video explaining the experiment scheme. And Bruce Conklin, from the University of California San Francisco, comments “on the road to a gene drive in mammals” also in Nature. Below are few excerpts from his News&Views. Continue reading
Chili peppers have happily entered our kitchens with their capsaicinoid content, since Cristoforo Colombo brought then back from Central America. Capsicum species however are labour-intensive and difficult to grow. They are also notoriously recalcitrant to biotechnological intervention. Tomatoes are much handier in comparison. The Capsicum and Solanum clades split at least 19 Mya ago but comparative genomics has revealed that tomatoes retain all the necessary genes for pungency. Why not to harness CRISPR power to turn tomatoes into capsaicinoid biofactories then? Continue reading
CRISPR contributed to Science’s Breakthrough of the Year and was also nominated for the Breakdown category by the same journal. The second nomination was an easy guess: He Jiankui and its baby-editing claim were also mentioned in Nature’s 10 for 2018. Much more interesting is the decision to celebrate cell-barcoding, the CRISPR-based technique used to track embryo development in stunning detail and over time. Continue reading
Tomorrow, the European Court of Justice is set to pronounce a verdict on the legal status of organisms produced through mutagenesis. In January, the opinion of the Advocate General Michal Bobek was variously interpreted, but scientists are hopeful that the judgment of Case C 528/16 will help the European Commission to reasonably regulate new breeding technologies such as CRISPR. Continue reading
Interview given to Anna Meldolesi (Corriere della sera, 15 May 2018)
The CRISPR biomedical duel between China and the US has been called “Sputnik 2.0”. Is Europe being left behind?
JD: As with any disruptive technology, there is intense competition to lead. However, unlike the space race, the CRISPR research effort is global and more collaborative. We consistently see key advances in CRISPR technology shared through scientific papers, written and read by research teams around the world. This collective approach has helped to democratize the technology. However, differing regulations across countries may impact how we ultimately translate research into real-world applications that can benefit the most number of people with the most need. Researchers in Europe have made valuable contributions to the development and application of CRISPR and will continue to play a role in establishing global standards. Continue reading
Let me come out. I enjoyed it, and I’m not much worried about so many people learning the word CRISPR from a popcorn movie. A little fun never killed any technology, and Rampage, by Brad Peyton, is less dumb than it may seem. Continue reading