Advanced cancer therapies would need new metaphors. War and space efforts – do you remember the War on Cancer and the Cancer Moonshot? – do not seem to reflect the spirit with which so many researchers pursue the strategy of small steps forward rather than chasing an illusory ultimate victory. The game of chess is perhaps a more fitting analogy, although checkmate is a long way off. The idea of genetically enhancing a patient’s immune defenses, in particular, has opened up exciting new possibilities especially for blood cancers (Car-T therapies) but is not without its limitations. One possible variant to increase the chances of success has been devised by Pietro Genovese’s group at the Dana Farber Cancer Institute in Boston and described in Nature a few months ago. If you can read Italian, please see also the December 2023 issue of Le Scienze, with my interview to Gabriele Casirati, first author of the Nature’s paper.
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First reactions to the first CRISPR therapy!
Seeing the forest for the CRISPR trees
Plant species are threatened by pathogens and pests, and the climate crisis is making things worse. CRISPR could help address some forest health threats, by making trees more resilient. But intervening in a complex ecosystem is a big decision. What are the alternatives? What are the uncertainties? Let’s think about a specific example, the American chestnut, and watch this iBiology video.
Koonin, CRISPR and the war
“Science in times of war: oppose Russian aggression but support Russian scientists” is the heartfelt article recently published by Eugene Koonin in EMBO Reports. Koonin is a leading evolutionary molecular biologist and a CRISPR pioneer. Born and raised in Moscow, he left the USSR a few weeks before it dissolved in 1991 and moved to the US where he works at the National Center for Biotechnology Information (NCBI-NIH).
He was elected Member of the National Academy of Sciences of the USA in 2016 and Foreign Member of the Russian Academy of Sciences (RAS) in 2019 but resigned from the second one at the end of February this year. You can read why in the excerpt below, and learn more about his outstanding contribution to science and the CRISPR field in this PNAS profile.
Continue readingArchealization by CRISPR
Alysson Muotri is a neuroscientist at the University of California, San Diego. His team is developing lentil-size, Neanderthalized mini-brains by using CRISPR + paleogenomics + organoids. After reading the paper published in Science last February, we asked him a few questions about the experiments of paleo-gene-editing he is doing at the Archealization Center.
Continue readingCrispy holidays, we’ll be back soon!
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So many CRISPR books so little time
Rumors are spreading about upcoming CRISPR books by Walter Isaacson (best known for his biographies of Albert Einstein and Steve Jobs) and other best-selling authors. In the meantime biotech-bibliophiles are enjoying the satirical side of cutting edge research with How to Build a Dragon or Die Trying. Continue reading
150 years after Mendel, say hello to CopyCat Mice
Do you remember the first lab mice equipped with (almost) working CRISPR-based gene drives? The results were pre-printed in bioRxiv last July, but the paper by Kimberly Cooper and colleagues is published in Nature today. The University of California San Diego has made a video explaining the experiment scheme. And Bruce Conklin, from the University of California San Francisco, comments “on the road to a gene drive in mammals” also in Nature. Below are few excerpts from his News&Views. Continue reading
From chili pepper to hot tomato?
Chili peppers have happily entered our kitchens with their capsaicinoid content, since Cristoforo Colombo brought then back from Central America. Capsicum species however are labour-intensive and difficult to grow. They are also notoriously recalcitrant to biotechnological intervention. Tomatoes are much handier in comparison. The Capsicum and Solanum clades split at least 19 Mya ago but comparative genomics has revealed that tomatoes retain all the necessary genes for pungency. Why not to harness CRISPR power to turn tomatoes into capsaicinoid biofactories then? Continue reading
CRISPR best and worst in 2018
CRISPR contributed to Science’s Breakthrough of the Year and was also nominated for the Breakdown category by the same journal. The second nomination was an easy guess: He Jiankui and its baby-editing claim were also mentioned in Nature’s 10 for 2018. Much more interesting is the decision to celebrate cell-barcoding, the CRISPR-based technique used to track embryo development in stunning detail and over time. Continue reading