MetaCRISPR, how to edit microbiomes

Jill Banfield and Jennifer Doudna (photo by Keegan Houser)

The best way to summarize the new metaCRISPR approach, recently published in Nature Microbiology, is the Twitter thread by Jill Banfield:

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Feng Zhang on how transposons hijacked CRISPR

CRISPR pioneer Feng Zhang walked through his current research projects at the national meeting of the Italian Genetics Association (AGI) on September 24. CRISPR associated transposases, retrovirus-like particles repurposed as delivery vehicles, the ancestry of CRISPR systems, and more. The first issue is probably the most fascinating. It’s actually amazing to see a new activity performed by some CRISPR systems: not to protect bacteria from viruses, but to help transposons jump into specific genome sites.

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