Craig Venter: many battles won, one left unfinished

Credit: Brett Shipe / J. Craig Venter Institute

Craig Venter was the first person to read his own genome (his full sequence was published in 2007). He was able to study his genetic predispositions and undergo the most advanced tests to verify their real-world relevance. In 2014, he launched a company called Human Longevity with the goal of building bridges between genetic sequences and diagnosis. In this way, by 2016 he had identified and defeated prostate cancer, but science and luck were not enough to save him a second time in 2026. When he passed away on April 29, he had not accomplished everything he had hoped to, but more than enough to secure a place in history, and perhaps even earn the respect of many of his former rivals.

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CRISPR microbes for climate and health

credit IGI

Jennifer Doudna’s Innovative Genomic Institute has received $70 million to explore a bold idea: combating climate change and other emergencies by modifying the microbial communities that live outside and inside us.

Bacteria are the true masters of the planet, for better or worse. Besides affecting our health in many ways, they are responsible for much of the methane emissions. This gas traps heat far more than carbon dioxide and is produced in large quantities by microbes that proliferate in environments associated with human activities (farms, landfills, rice paddies). The good news is that methane is short-lived, so reducing its emissions would have a rapid and substantial effect on global warming. What tools do we have at our disposal to try to pursue such an ambitious goal?

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MetaCRISPR, how to edit microbiomes

Jill Banfield and Jennifer Doudna (photo by Keegan Houser)

The best way to summarize the new metaCRISPR approach, recently published in Nature Microbiology, is the Twitter thread by Jill Banfield:

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CasX: the smaller the crispier

cas treeTime will tell if it is going to become the preferred enzyme for genome editing or just another useful tool in the expanding CRISPR kit. But the future of CasX looks bright. It is much smaller than the nucleases that have provided a foundation for this technology. Being fewer than a thousand amino acids, it offers clear advantages for delivery in comparison with Cas9, that is over 1,300 Aa. Continue reading