Picture of the week

bimaternal pups

Healthy adult bimaternal mouse (born to two mothers) with offspring of her own.
Credit: Leyun Wang

Single-gender worlds will remain a sci-fi fantasy. Gay and lesbian couples won’t become parents this way for the foreseeable future. This kind of manipulation is just too risky for humans. But unisexually reproducing mice are an impressive accomplishment, and CRISPR stands out again as a powerful research tool, opening up brand new possibilities for the study of genomic imprinting. For further details, please see the STAT News article about the Cell Stem Cell paper by Zhi-Kun Li.

China did it once again

huang

Junjiu Huang is back. Two years later, Protein & Cell publishes another study by the team which first edited human embryos in 2015 sparking uproar. They targeted the gene responsible for beta thalassemia, once again. This time, however, in place of using embryos discarded by fertilization clinics, they resorted to cloning. Furthermore, Huang and colleagues employed a CRISPR variant called base editor changing a single DNA letter without even cutting the double helix. The news is circulating among experts but has not yet attracted the media spotlight. Stem cell specialist Alessandro Bertero has brought it to the attention of CRISPeR Frenzy. According to the researcher involved in the British experiment just published in Nature, the latest paper from China is far from perfect but it’s quite interesting anyway (see his technical comment below). Continue reading