A wolf of a year

You remember, right? They were created through gene editing. Almost immediately, the debate kicked off: is this really de-extinction? Are they really dire wolves? Of course, dire wolves are fictional creatures, while “de-extinction” is a neologism that can be interpreted more or less strictly. To avoid getting stuck in a semantic argument, let’s just say this was a case of recovering selected genetic traits from the genome of an extinct species that later inspired a sci-fi series. Setting the terminology aside, a year on from the New Yorker and Time articles, the real question is: how are these very special pups doing?

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A fresh graphic take on gene editing

Tired of illustrating articles and PowerPoint presentations on genome editing with the usual genetic scissors and Swiss Army knives? You might not know that the Innovative Genomics Institute, founded by CRISPR inventor Jennifer Doudna, offers images created by its graphic designers free of charge for educational and non-commercial use. Take a look at the Science × Art section of their website and their illustrated glossary.

CRISPR-GPT: a copilot for editing

Nature Biomedical Engineering has introduced a chatbot specifically designed to help beginners with their first experiments and to support experienced researchers in their work.

Since it was first described in Science in 2012, in the landmark paper by Emmanuelle Charpentier and Jennifer Doudna, the success of the CRISPR technique has been summed up with a handful of adjectives: cheap, precise, easy to use. But since everything is relative, it’s worth asking: how easy, and compared to what? When measured against previous genetic editing platforms, CRISPR is far simpler to apply. Whereas only a few highly specialized centers could once perform these experiments, with CRISPR a standard lab, the basic skills of an ordinary biologist, and solid familiarity with bioinformatics may be enough. Still, novices need guidance, and even seasoned researchers can run into problems.

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CRISPR news from the world

A selection of news we missed during August. Reuters reports on the controversy surrounding horses edited by Kheiron Biotech to enhance their muscles. In Argentina, veterinary reproductive technologies are cutting-edge, and the use of cloning in horse breeding is accepted. Still, for now, genetically edited animals are not allowed to compete in polo.

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Is RNA unwelcome? Let’s hope it’s a misunderstanding

source: Nature Biotechnology

Rumor has it that RNA has fallen out of favor politically, presumably as a key molecule for vaccines against Covid, making it an unwelcome symbol to the U.S. administration in the era of Robert F. Kennedy Jr. and Donald Trump. According to reports, U.S. researchers have been advised to specifically remove references to messenger RNA from research projects competing for public funding.

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