Anti-terror training for CRISPR


Safe genes” is what it’s called, and it’s a program for the responsible development of gene editing technologies funded with $65 million by the US Defense Advanced Research Projects Agency (Darpa). The grant will go to seven teams including top scientists such as CRISPR co-inventor Jennifer Doudna and synthetic biologist George Church. Finding reversible ways to control gene editing is a national security issue, in the event CRISPR falls into the wrong hands. But Darpa intends also to foster peaceful applications, by encouraging innovation and mitigating risks which might accidentally arise in civilian labs. Think of new CRISPR variants that can distinguish between highly similar genetic sequences, or molecular mechanisms to finely modulate the technology of gene drives, which is experimented to propagate modifications through entire populations.  Continue reading

Everything you always wanted to know about gene drives

OLYMPUS DIGITAL CAMERAMosquito nets are not enough, vaccines are late to come, land reclamation in Africa is a challenge. But there is a new hope for defeating malaria, coming directly from the most advanced CRISPR frontier. The trick is a kind of genetic chain reaction fuelled by genetic elements called “gene drives”. Researchers are experimenting their power with the aim of crashing the number of mosquitoes responsible for Plasmodium transmission, by spreading genes that are bad for Anopheles gambiae. A gene behaving in Mendelian way has a 50% chance of being passed on from parent to offspring, but it can virtually reach 100% with a little help from a drive. Thus a gene designed to damage a harmful species can propagate within a few generations with a domino effect, until the population collapses. One of the founders of this futuristic strategy is an Italian molecular parasitologist: Andrea Crisanti, of the London Imperial College. We asked him to explain times and ways, strengths and risks of this approach. Continue reading