Soon after the arrival of CRISPR, a report from Harvard compared the new gene-editing technique and its older sister side by side. As reported by Kevin Davies in the book “Editing Humanity,” CRISPR won convincingly, and this paper helped boost CRISPR’s popularity. This video shows that nowadays CRISPR is considered the best in terms of ease of design, ease of experimental setup, and flexibility. TALEN, however, is more precise. What about efficiency? Well, it depends. CRISPR works better in the less-tightly wound regions of the genome, but according to a recent Nature Communications paper, TALEN can access the heterochromatin region better than CRISPR. The study by Huimin Zhao and colleagues at the University of Illinois Urbana-Champaign adds to the evidence that the more (tools), the better.