Genetic gain is a team game

[The number of studies investigating the impact of modifying one or a few genes on the yield of a crop]

Some champions can make a difference, but to win matches and tournaments, there must be chemistry among the players. The same happens for the effort to increase the productivity of crop plants. Hunting down the single key gene, hoping it will work the miracle, is not enough. One must focus on the harmony of genetic combinations, through approaches that marry the most advanced technologies with agronomic knowledge. In short, handling DNA and test tubes is fine, but it is equally important to know what actually works when the plants reach the field. That’s the message a group of influential researchers such as Pamela Ronald of the University of California at Davis delivered to the pages of Nature in a commentary provocatively titled “Genetic modification can improve crop yields – but stop overselling it”.

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Edited crops in EU – Have your say

The European Commission is collecting comments on the proposed regulation on New Genomic Techniques (NGTs) presented on 5 July. On this page you will find all the documents you need to form an opinion: from the criteria for establishing when a NGT plant is comparable to a conventional plant, to calculations on the costs of coexistence for organic producers (see in particular the Impact assessment report). The feedback received during the consultation period (8 weeks, extendable) will be summarised by the European Commission and presented to the European Parliament and the Council to feed into the legislative debate. In general, CRISPeR Frenzy appreciates the proposed regulation, especially for its focus on the promised benefits of NGTs in terms of environmental sustainability.

A brief guide to the messy Italian debate on NGTs

There is great disorder under the heavens of new biotechnology. Judging by the Italian debate on genetic innovation in agriculture, it seems that we no longer know what to call what. We are waiting for the European Commission to present its proposal to regulate ‘new genomic techniques’ (NGTs) on 5 July (see the leaked draft here). But in the meantime, on 9 June, the Italian Parliament approved a regulation in favour of experimentation with ‘assisted evolution techniques’ (TEAs), which are the same thing. However, if you read the official wording (9 bis, drought decree law) this expression is missing: instead, it refers to the deliberate release into the environment for experimental purposes of ‘organisms produced by genome editing techniques through site-directed mutagenesis or by cisgenesis’.

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NGT-leaks: EC confidential proposal circulating online

The European Commission’s proposal for an updated regulatory framework for New Genomic Techniques is due on 5 July, but someone leaked the confidential document online. In a nutshell, if the modification could also have been achieved naturally or by conventional methods, and the plant has the same risk profile as its conventional counterpart, it should be treated similarly to conventional plants and differently from GMOs (it would not require authorisation, risk assessment, traceability, labelling as GMO, but would be placed in a transparency register). For plants in which editing or cisgenesis has led to results that differ from conventional ones, the current GMO rules apply. You can read the Genetic Literacy Project’s explanation here.

Please note a couple of things environamental NGOs and organic producers should like: herbicide-tolerant NGT plants would remain subject to GMO rules, and all NGT plants would remain subject to the prohibition of use of GMOs in organic production.

Editing by grafting – a new GM-free strategy

The practice of grafting is ancient, Cato the Censor already wrote about it over two thousand years ago. CRISPR, on the other hand, is a young invention that will empower the future. A new GM-free editing strategy could blossom from the meeting of the two. Let’s call it editing by grafting. Don’t miss the paper published in Nature Biotechnology
by Friedrich Kragler’s group and Caixia Gao’s accompanying commentary. The process is shown in this video, posted on the Plamorf consortium website.

Would you buy a CRISPR salad from these men?

The company which developed the new vegetable (and is working on new varieties of cherries and berries) was founded by CRISPR top scientists David Liu, Keith Joung and Feng Zhang

By now it seems official. The first CRISPR plant to debut in the US market will not be a commodity for industry or intensive livestock farming, as was the case with classic GMOs in the 1990s. This time genetic innovation enters on tiptoe, with a food product designed for discerning consumers. A new type of salad, as nutrient-rich as a wild misticanza but without the bitter notes that usually relegate brassicas to foods to be eaten cooked (see here).

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Apomixis, the Holy Grail is at hand

For a long time, it was no more than a botanical curiosity, of interest to a few scholars with a passion for taxonomy and evolution. Today, it has become the Holy Grail of agricultural genetics. We are talking about apomixis, i.e. the ability to produce viable seeds that are completely identical to the mother plant, bypassing the need for fertilisation. “Research has been going in waves, now we are on the crest,” says Emidio Albertini, an apomixis expert at the University of Perugia and the organiser of a recent workshop on the subject at the Plant & Animal Genome Conference (San Diego, 13 January 2023).

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UK embraces CRISPR crops

© Brian Bould/

While the European Union still grapples with the political complexity of revising its regulatory framework on GMOs, post-Brexit Britain has already made up its mind. In late March, London passed the Genetic Technology (Precision Breeding) Act, with the royal assent and to the delight of British researchers. For those familiar with the history of the GM controversy, this is a momentous event with strong symbolic value.

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A tale of three Gs – grape, germs and genetics

“There is more wit in these bottles than in all the books of philosophy in the world,” wrote Louis Pasteur in 1843, looking forward to the pleasure of toasting with a friend (Charles Chappuis). The French microbiologist, whose bicentenary of birth was celebrated last year, was one of the fathers of the science of wine, as well as of germ theory. I wonder what he would write today, knowing how much progress is being made by geneticists to preserve the spirit of ancient vines while protecting them from the evils of diseases.

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