CRISPR diagnostics is coming

Nature was right in choosing CRISPR diagnostic as one of the seven technologies to watch in 2022. The latest news is a test called mCARMEN, described in Nature Medicine. Pardis Sabeti (Broad Institute/Harvard), Cameron Myhrvold (Princeton University) and colleagues adapted a massively multiplexed technology presented in 2020 to be “faster, more sensitive and more easily implemented in clinical and surveillance labs”.

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CRISPR news: the good, the bad and the ugly

read-the-newsHistory in the making: student experiment edits DNA with CRISPR technology in space (Iss national lab blog)

Emails reveal that a facility in Dubai and others have asked geneticist He Jiankui for help in gene-editing embryos (The Scientist)

New worries about CRISPR babies: gene edits might have shortened their life expectancy (Nature)

CRISPRing in the womb

pregnant-2640994_960_720It’s another CRISPR first: fixing a hereditary disease in utero. Scientists from Pennsylvania University and the Children’s Hospital of Philadelphia used a base editor to rescue tyrosinemia in fetal mice. “The results of this proof-of-concept work demonstrate the possibility of efficiently performing gene editing before birth, pointing to a potential new therapeutic approach for selected congenital disorders,” Avery C. Rossidis and colleagues write in Nature MedicineContinue reading

CRISPR and the cancer link. Who said what?


Credit: Ernesto del Aguila III, National Human Genome Research Institute, NIH

A pair of papers published in Nature Medicine have caused a stir about CRISPR-edited cells lacking a well-known tumor suppressor gene. STAT is doing an online chat next week to follow up the news. In the meantime, this is a sample of how the CRISPR community is commenting the story. Continue reading