The pandemic has accelerated progress in the field of lipid nanoparticles (LNP), and now CRISPR-based treatments are set to reap the benefits.
Continue readingLipid nanoparticles beyond Covid vaccines
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Tag Archives: COVID-19
CRISPR diagnostics is coming
Nature was right in choosing CRISPR diagnostic as one of the seven technologies to watch in 2022. The latest news is a test called mCARMEN, described in Nature Medicine. Pardis Sabeti (Broad Institute/Harvard), Cameron Myhrvold (Princeton University) and colleagues adapted a massively multiplexed technology presented in 2020 to be “faster, more sensitive and more easily implemented in clinical and surveillance labs”.
Continue readingOrganoids & CRISPR in the toolbox of virologists
Human gut organoids infected with SARS-CoV-2 (Credit: Joep Beumer/Hubrecht Institute)
“Virologists have infected millions of miniature organs with SARS-CoV-2, to learn how the virus wreaks havoc and how to stop it,” writes Smriti Mallapaty in the latest issue of Nature. In one study, published in Science Immunology in 2020, researchers used CRISPR in gut organoids to identify two proteins (TMPRSS2 and TMPRSS4) that facilitate the virus entry into human cells, together with the ACE2 receptor. “Other labs are knocking out ACE2 entirely, to see whether the virus can still get in”. Here the full text of the news feature.
What a Cas for STOPCovid
Alicyclobacillus used to be the problem (for fruit juice manufacturers). Now is the solution (for CRISPR-diagnostics). Read the MIT News on STOPCovid, the first FDA-approved test based on CRISPR. Here’s an extract.
Continue readingCRISPR milestone: FDA approves first diagnostic test
May 7th 2020 will be remembered as a good day for CRISPR. Yesterday the first CRISPR/Cas-based test received Emergency Use Authorization from the U.S. Food and Drug Administration. The Sherlock SARS-CoV2 kit works by programming a CRISPR enzyme to detect the coronavirus genetic signature, providing results in about one hour. Quickly and cheaply indeed, as the materials for one test cost about $6.
Continue readingWhen CARMEN met the coronavirus
Say hello to CARMEN: a massively multiplexed, Cas13-based technology for nucleic acid detection, out yesterday in Nature. Its name stands for Combinatorial Arrayed Reactions for Multiplexed Evaluation of Nucleic acids, and it allows us to test many amplified samples for the presence of many viral sequences by using miniaturized detection reactions that self-organize in a microwell array. Sars-Cov2 included.
Continue readingThe CRISPR community and Covid-19
Researchers from all the life sciences are turning their attention to the pandemic, and the CRISPR community is no exception. The latest CRISPR Journal‘s editorial presents a few of the projects that are showing promise, and others are probably going on. Kevin Davies and Rodolphe Barrangou also comment on the cancellation or postponement of several key conferences in the next few months due to Covid-19, especially the CRISPR 2020 meeting in Paris. They applaud all the scientists who are battling this disease in myriad ways and promise: we’ll meet again.
CRISPR application to infectious diseases
CRISPR holds promise for the treatment of cancer and inherited disorders, as you know, but what about infectious diseases? It can do many useful things indeed, according to this review by Jeffrey Strich and Daniel Chertow, published in the Journal of Clinical Microbiology.
Continue readingDoudna in the time of Covid
how CRISPR might help and a forthcoming statement on IP rights
The CRISPR race for coronavirus tests
PCR, POC testing, CRISPR diagnostics, immunoassays. Many tests much confusion. Thankfully, Nature Biotechnology and the Financial Times bring some clarity on fast, portable tests to curb coronavirus pandemic.
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CRISPeR FRENZY 