
As far as we know, the passing of controversial DIY-bioentrepreneur Aaron Traywick has nothing to do with CRISPR. The cause of death is still unknown, and there is not even much information about the alleged herpes vaccine he self-injected a few months ago. According to media reports, it consisted of “live attenuated virus with a missing protein” or maybe contained “engineered copies of the virus DNA code.” Injecting yourself with an unproven concoction is obviously a bad idea, with or without CRISPR. The death news indeed puts biohacking at a crossroads, according to the Atlantic. But even more worrying is the MIT Technology Review scoop that Traywick has been planning human tests of a CRISPR therapy for lung cancer at a wellness center in Tijuana, Mexico. Stem cells researchers have raised the alarm over and over again in the past on unregulated clinics preying on desperate patients in lenient countries. The specter of nascent CRISPR-medical tourism in search of unproven treatments is an urgent issue to tackle.

Everyone knows IPCC, the forum created under the auspices of the United Nations to review the state of knowledge on climate change, draw scenarios on its impact, and compare alternative policies. Does the world need a similar body for the biotech revolution ahead, as claimed by Sheila Jasanoff and J. Benjamin Hurlbut in
“Uh Oh. CRISPR might not work on people”. A title like this on the 

Faster, better, cheaper is a motto adopted by Nasa that perfectly fits CRISPR as well. The most popular technique for genetic modification, in fact, has the reputation of being quick, affordable and precise. This deserved good name was unexpectedly tarnished by a study questioning the technology precision, published in the June issue of Nature Methods. However, reports about CRISPR’s demise have been greatly exaggerated, to paraphrase Mark Twain. Just over a month later, three analyses challenging the controversial study are already available in the pre-publication archive bioRxiv, and Nature Methods has alerted its readers about the criticisms received by publishing an
Perfection is not of this world, and no technology is perfect. But tolling the bell for CRISPR because of a single preliminary study last week was premature at best. Many voices are doubting the meaning of the Nature Methods paper reporting “hundreds of unintended mutations” putatively caused by genome editing. Some researchers have already announced that critical analyses and rebuttals are forthcoming.