Germany debates CRISPR

leopoldina

Germany stands out as the European country most interested in fostering an informed debate on CRISPR many uses. Today an interdisciplinary group of experts from the German National Academy of Sciences (Leopoldina) has published a Discussion Paper entitled “Ethical and legal assessment of genome editing in research on human cells”.  Experiments involving human embryos are prohibited by law in the country but the document suggests a possible compromise. Research should be permitted on “orphaned” embryos created for reproductive purposes but no longer going to be used for reproduction. In February the German academy co-organized a meeting on edited plants, discussing what kind of regulation would be suitable. In 2005 they published a statement on “The opportunities and limits of genome editing” and another one on molecular plant breeding. According to a Leopoldina official press-release, the annual assembly “will be intensively addressing the topic of genome editing” later this year.

Six questions for the YouTuber singing CRISPR

The best explanations of CRISPR ever heard in 413 words, or 4 minutes and half of listening, is not an article from a prestigious science journal but a YouTube video where the wonders of the new technique of genetic modification are sung a cappella. We couldn’t not interview the author. Tim Blais was a fresh physics graduate when he turned its science-music into a professional activity by means of crowdfunding. That about CRISPR is probably his best video and has quickly become viral.    Continue reading

Light bulb or bomb?

 

augias bomba atomicaCRISPR ’s debut in the cultural programming of the Italian television occurred at “Quante storie”, a 30 minutes book show aired by the public broadcasting company (Rai 3, 23 March 2017). It went with a genuine interest into understanding the science of genome editing and many questions from the classic repertoire concerning biotechnology, from worries about economic interests at play (but if we want drugs, the pharma industry must be there) to the risk of using the new technique for eugenics purposes (the long shadow of Nazism still makes us think blond children would be favored). Continue reading

Edited crops, organic farming and Greenpeace Mag

fiblThe German publication Greenpeace Magazin interviewed Urs Niggli, the director of FiBL, a leading research institute on organic agriculture. In his opinion genome editing is going to be useful and edited crops should not be classified as GMOs but assessed on a case by case basis. The text below by Frauke Ladleif was translated and posted with the kind permission of Greenpeace Magazin/Hamburg. Continue reading

Editing cancer at IEO

pelicci quadrotto

The second leg of the journey among leading labs takes us to the European Institute of Oncology in Milan. CRISPR’s potential is particularly exciting for oncology, as tumors are caused by multiple mutations and the new technique of genome editing is multiplexable, meaning it may target several genes at the same time. IEO scientific co-director Pier Giuseppe Pelicci has shared his enthusiasm with us.

“In our lab we are using CRISPR in 3 broad research areas. In the first area we follow the classic way, by disrupting the genes we want to study in order to understand their functions. CRISPR can do it much better than the previous techniques. It’s fast, very cheap and easy to handle. Before CRISPR we could carry out an experiment every 6 months, after CRISPR we can do one every week. It’s like altering the flow of time.” Continue reading

News review: edited crops in Science and Nature

news reviewThis week the royal couple of science journals have turned  the spotlight on CRISPR’s potential for agriculture. “Genome editors take on crops” and “CRISPR, microbes and more are joining the war against crop killers” are the titles respectively chosen by Science and Nature. The first one is a perspective by Armin Scheben and David Edwards from the University of Western Australia. “Improved crops are urgently needed to meet growing demand for food and address changing climatic conditions”, they write. The global population is expected to rise from 7.3 to 9.7 billion by 2050 and a global increase in crop production of 100 to 110% from 2005 levels will be required. Continue reading

The art of learning from microbes

ecoli-1184pxBy Antonio Polito

Do you remember Dolly, the sheep cloned 20 years ago? I was one of the many going on pilgrimage to visit her in its golden prison at the Roslin Institute, near Edinburgh. And like other reporters I was worried while talking with Dolly’s “father” Ian Wilmut, about practical and ethical implications of the breakthrough, which appeared huge at the time. Media were boiling with awe and outrage: is human cloning the next step? It would be evil or blessing? Are we playing God?  Continue reading

Targeting Huntington at CattaneoLab

huntingtonCRISPR is radically changing the way researchers work, by allowing better, faster, and cheaper experiments. This blog will tell, among other things, how leading labs are using the most popular technique for genome editing. Let the dance begin with the Laboratory of Stem Cell Biology and Pharmacology of Neurodegenerative Diseases of the University of Milan (CattaneoLab). The group directed by Elena Cattaneo is busy unveiling the molecular basis of neurodegeneration in Huntington’s disease with the help of CRISPR, as pharmacologist Chiara Zuccato explains.

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Crazy 4 CRISPR


maxresdefaultStunning, revolutionary, momentous
: these are some of the adjectives sprinkled by leading international journals over CRISPR. In the last few years the new technique of genetic modification has been mentioned in hundreds of studies, not counting the articles published in the lay press. The keyword CRISPR (pronounced crisper) produces 6 million Google search results. Being the author of a book and a blog on the topic I can be dubbed as a genome-editing-enthusiast, but the title and logo I’ve chosen for my news and views diary are a way of kidding about the frenzy. The mug standing out on the homepage echoes the famous claim “Keep calm and carry on”. Keep calm and crispr on. When major scientific achievements arrive, or unexpected obstacles come between, because there are always some, or controversy erupts over this or that application of the technology, it won’t be the end of the world. Don’t panic and keep on crispring. Continue reading

Forthcoming

cover-libroRefining, chiselling, correcting DNA letter by letter. You can do it simultaneously in dozens of selected sites, or in one place, leaving no trace. A new kind and powerful technique is changing the face of biology. Cheap and easy to handle but precise as a laser. It allows reaserchers to change living organisms as they wish, by carefully targeting their DNA. It doesn’t bombard them by means of random mutations, it doesn’t cut and sew the DNA in a traditional way, as in the past. Will it transform medicine, agriculture and the world as we know it? Enthusiasm and fears are chasing each other, and this book explains the unfolding revolution. Welcome to the age of CRISPR. Continue reading