
The second leg of the journey among leading labs takes us to the European Institute of Oncology in Milan. CRISPR’s potential is particularly exciting for oncology, as tumors are caused by multiple mutations and the new technique of genome editing is multiplexable, meaning it may target several genes at the same time. IEO scientific co-director Pier Giuseppe Pelicci has shared his enthusiasm with us.
“In our lab we are using CRISPR in 3 broad research areas. In the first area we follow the classic way, by disrupting the genes we want to study in order to understand their functions. CRISPR can do it much better than the previous techniques. It’s fast, very cheap and easy to handle. Before CRISPR we could carry out an experiment every 6 months, after CRISPR we can do one every week. It’s like altering the flow of time.” Continue reading
This week the royal couple of science journals have turned the spotlight on CRISPR’s potential for agriculture. “Genome editors take on crops” and “CRISPR, microbes and more are joining the war against crop killers” are the titles respectively chosen by
By Antonio Polito
CRISPR is radically changing the way researchers work, by allowing better, faster, and cheaper experiments. This blog will tell, among other things, how leading labs are using the most popular technique for genome editing. Let the dance begin with the Laboratory of Stem Cell Biology and Pharmacology of Neurodegenerative Diseases of the University of Milan (
Stunning, revolutionary, momentous: these are some of the adjectives sprinkled by leading international journals over CRISPR. In the last few years the new technique of genetic modification has been mentioned in hundreds of studies, not counting the articles published in the lay press. The keyword CRISPR (pronounced
Refining, chiselling, correcting DNA letter by letter. You can do it simultaneously in dozens of selected sites, or in one place, leaving no trace. A new kind and powerful technique is changing the face of biology. Cheap and easy to handle but precise as a laser. It allows reaserchers to change living organisms as they wish, by carefully targeting their DNA. It doesn’t bombard them by means of random mutations, it doesn’t cut and sew the DNA in a traditional way, as in the past. Will it transform medicine, agriculture and the world as we know it? Enthusiasm and fears are chasing each other, and this book explains the unfolding revolution. Welcome to the age of CRISPR.