CRISPR Wow: Arabidopsis Dresses Up

For scientists, it is a model organism—perfect for research because it grows fast, self-pollinates, and has a small genome that is easy to modify. In fact, it is the most studied plant in the world, the first to have its DNA sequenced, a true diva of genetics. To everyone else, it is an anonymous weed: among countless botanical wonders, Arabidopsis thaliana hardly stands out, being so small and with such unremarkable flowers.
But the foundational knowledge is there, and so are the biotechnological tools. So, why not give its colorless, modest bloom a gala makeover, with petals to make a rose jealous? This idea sparked the imagination of Nick Desnoyer from the University of Zurich. With a little breeding and a touch of CRISPR, he created a plant with the genetic backbone of Arabidopsis but adorned with a sumptuous corolla.
Don’t miss his visually stunning thread on X and bluesky where he announces a bio-art project set to blossom in 2025.

CRISPR on the Road to Mars

Future space exploration will depend in large part on using organisms capable of surviving in extreme conditions. One source of inspiration for achieving this goal is the tardigrade, a tiny invertebrate that is a champion of endurance and could lend its genes (and perhaps some superpowers) to other species designed to feed astronauts and provide useful substances.

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CRISPRing at school – for 2$

Forget Odin, the controversial kit that was being sold online by controversial “biohacker” Josiah Zayner (getting people to play around with developing antibiotic-resistant bacteria is certainly not a good idea). At Stanford University they have developed a CRISPRkit for cell-free in vitro experiments that is easy and safe because the target is a harmless pigment. And the great thing is that it costs less than an American coffee (two dollars).

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Googling CRISPR over the years

More than a decade after its discovery-invention by Jennifer Doudna and Emmanuelle Charpentier, interest in CRISPR continues to remain remarkably high, judging by how many times this word is searched on Google (credit @datadynamix_). To navigate the timeline, see the most important dates below.

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OpenCRISPR – gene editing meets AI

OpenCRISPR, credit Profluent

Natural evolution has had four billion years to experiment with living matter. From now on, artificial intelligence will also help expand the catalog of possible and desirable molecules. These so-called ‘language systems’ are no longer limited to producing text or images, as exemplified by ChatGPT or Midjourney. They can now be instructed and utilized to design new proteins, thereby potentially creating improved CRISPR scissors.

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Resurrecting extinct species _ where do we stand?

Beth Shapiro is chief scientific officer at Colossal Biosciences

Plans to genetically bring mammoths and other vanished animals back to life have scientific stakes far beyond the imagery of Jurassic Park

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Live Dance Performance – The Choreography of CRISPR

If you are in Cambridge, Massachusetts, don’t miss the live dance performance to be held at the MIT Museum on March 16th. The Choreography of CRISPR is all about “twisting, cutting, inserting, copying, repeating, palindromes, and cluster”, “an intricate dance of spiraling and folding patterns” (you can watch a minute from the première on the facebook page of the NYC-based contemporary dance company Pigeonwing Dance; choreography by Gabrielle Lamb, original music by James Budinich).

Patient-pioneer in the pantheon of medicine

According to Fyodor Urnov, she should be added to “the pantheon of names inscribed in golden letters in the history of biomedicine.” That list includes other pioneering patients such as James Phipps (the boy vaccinated by Edward Jenner), Albert Alexander (the first human treated with penicillin), Louise Brown (the first test tube baby) and Emily Whitehead (the first recipient of CAR-T cells). Now the CRISPR Journal made the unusual decision to put her on the cover.

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