Jonathan Weissman and colleagues used a CRISPR-based method to link each expressed human gene to its function in the cell. Here’s our suggested readings to learn more: the paper in Cellby Josepg Replogle et al. the Twitter thread by Joseph Replogle MIT News (by Eva Frederick) and GenEngNews.
Reversing three genetic diseases in the animal model without even changing a single DNA letter. A Salk Institute team did it by bringing together two of biomedicine’s hottest trends. One is the CRISPR technique, which edits target genes through a programmable molecular machine named Cas9. The other is epigenetics, i.e., the study of chemical modifications that switch genes on and off without altering their sequence. It’s called epigenetic editing, because corrections are precise as in manuscript revision and occur at a level that is over (epi- in Greek) genetics. Continue reading →
In horror films of the 1950s mutant insects were a nightmare. Now they are a dream that is becoming a reality, at least for those interested in studying the molecular bases of social behaviors. Two teams have just succeeded in modifying ants DNA by knocking down their olfactory system and consequently putting their social interactions in disarray. The experiments, published in August in Cell, herald the beginning of a new scientific adventure: ants are set to become the model organism for eusociality studies in the post-genomic era. Continue reading →