The University of Verona’s edited vines are already in the field, and soon it could be the turn of the Edmund Mach Foundation and CREA-CNR. Once again, the focus is on Chardonnay, edited to resist downy mildew (with a double knock-out approach) or powdery mildew. I spoke with the key figures of this new chapter in Italian research: Mario Pezzotti, Sara Zenoni, Umberto Salvagnin, Riccardo Velasco, and Vittoria Brambilla. Returning to write for Nature Biotechnology is a joy for me, especially because this time, Italy is leading the way in innovation rather than holding it back, as in the past. Prosit!