Xenografts – here’s where we stand

Surgeon Jayme Locke and immunologist Megan Sykes

David Bennett, the first patient transplanted with a genetically edited pig heart, died on March 8 last year, two months after the surgery, presumably from a latent pig virus (a problem that does not seem hard to solve with more stringent protocols and screening, as Linda Scobie explained to me a few months ago). Since then, experimental transplants have continued in brain-dead patients who had donated their bodies to research. After xenokidneys with a single genetic modification transplanted in late 2021, in the summer of 2022 it was the turn of ten edits xenohearts. The state of the art now is that the potential of the approach still appears high, as does the morale of specialists.

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CRISPR WOMEN – faces and feats


They may have lost the latest round in the patent dispute, but Jennifer Doudna and Emmanuelle Charpentier will be forever celebrated as the inventors of CRISPR.
In “The Code Breaker” by Walter Isaacson, Doudna tells how a school’s guidance counselor tried to discourage her from studying chemistry at college: “Girls don’t do science.”
The Nobel prize came a few decades and many brilliant experiments later, it’s the first shared by two women. The institute founded by Doudna (IGI) is now launching an ad hoc incubator specifically to enhance gender equity in bio-entrepreneurship. Jennifer and Emmanuelle are unquestionably great role models for girls interested in science and started a wave of discoveries and inventions by female scientists.
In the slideshow below, you can meet some of the brightest women in CRISPR.

First paper and more xenotransplantation news

photo credit: University of Alabama at Birmingham

The first paper on a CRISPR xenotransplant is out in the American Journal of Transplantation. It’s about two swine kidneys with 10 modified genes transplanted into a dead brain man as a proof of concept. The surgery was performed on September 30 by Jayme Locke and colleagues from the University of Alabama at Birmingham.

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