Jennifer and Jim: Mr. DNA told by Lady CRISPR

The fascination with biochemistry sparked by The Double Helix, the thrill of her first invitation to Cold Spring Harbor, and the melancholy of her last visit to the disgraced genius.

While we wait for Nathaniel Comfort’s upcoming biography of James Watson, Jennifer Doudna’s story in The Code Breaker by Walter Isaacson offers a revealing lens on the scientist whose outstanding legacy is overshadowed by his offensive claims about intelligence and race. Doudna crossed paths with Watson three times — moments that shaped both her imagination and her opinion of the man who helped discover the structure of DNA.

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It takes two to think

Watson & Crick for the double helix. Doudna & Charpentier for CRISPR. Karikó & Weissman for RNA vaccines… Do two people think better than one or even many? Itai Yanai and Martin J. Lercher suggest so in Nature Biotechnology.

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From the double helix to CRISPR: Watson updates his genetic revolution

watson-book

Let’s read these letters: DNA. Who’s the first person who comes to your mind? The chances are high that you say James Watson, the politically incorrect half of the pair that in 1953 unveiled the double helix and the molecular basis of inheritance. It can be argued that this discovery opened the path leading to the invention of CRISPR sixty years later. The scientist who personifies one of the biggest turning points for human culture, now eighty-nine, has written what he thinks of the young technology for genome editing in the latest edition of “DNA. The Story of the Genetic Revolution “. The book, first published in 2003, has just been updated to cover the latest science and technology developments. Continue reading