MicroRNAs won Victor Ambros and Gary Ruvkun the 2024 Nobel Prize in Medicine. Thomas Cech (Nobel Laureate for the discovery of catalytic RNA) has found a fun way to explain how they work. His book, which I reviewed a few weeks ago, is a mine of insights and information. Here is a small excerpt.
RNA interference, mRNA vaccines, RNA-guided editing. These are just some of the fields of biomedical research that have exploded in recent years and brought RNA out of the projected shadow of the most famous nucleic acid: DNA. Credit for the ongoing scientific and technological revolution goes to researchers such as Thomas Cech, who have been able to look beyond the double helix and, in many cases, have earned Nobel prizes (the latest being Katalin Karikό for the anti-Covid vaccine). But we also owe a nice gratitude to the strange critters who first exhibited some unexpected phenomena that later became of universal interest.